What does this research mean for the field?

Non-insulin-dependent diabetes mellitus is significantly associated with a higher prevalence of asymptomatic ischemic heart disease and myocardial infarction in older adults. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To evaluate the prevalence of ischemic heart disease in older adults with different glucose tolerance statuses.

March 1, 1990Circulation

Resting electrocardiographic abnormalities suggestive of asymptomatic ischemic heart disease associated with non-insulin-dependent diabetes mellitus in a defined population.

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Why the study?

Is non-insulin-dependent diabetes mellitus associated with a higher prevalence of asymptomatic ischemic heart disease compared to normal glucose tolerance in older adults?

Population

2,223 white men and women, aged 50-89 years, in the Rancho Bernardo cohort

Comparison

Non-insulin-dependent diabetes mellitus or… vs Normal glucose tolerance

Design

Cross-sectional

Authors

CSChrista Scheidt‐NaveGeneral / Preventive / Lipids EBElizabeth Barrett‐ConnorPennington Biomedical Research Center DWD L WingardCenters for Disease Control and Prevention

Discussion

Member takes

Implication

Supports heightened vigilance for asymptomatic IHD in older NIDDM adults; confirms prior observations but leaves screening utility open.

Key Points

To evaluate the prevalence of ischemic heart disease in older adults with different glucose tolerance statuses.
Analyzed data from 2,223 adults aged 50-89 in Rancho Bernardo cohort (1984-1987).
Classified glucose tolerance status using WHO criteria and defined IHD via ECG and questionnaires.
Compared prevalence of IHD among those with non-insulin-dependent diabetes mellitus and impaired glucose tolerance.
NIDDM associated with significantly higher prevalence of IHD (OR 2.08 [1.22, 3.56]; p = 0.009) in women.
Men with NIDDM had higher prevalence of asymptomatic IHD (OR 1.75 [1.10, 2.81]; p < 0.05).
Findings persisted after controlling for medications and major IHD risk factors in women.

Structured PICO

Is non-insulin-dependent diabetes mellitus associated with a higher prevalence of asymptomatic ischemic heart disease compared to normal glucose tolerance in older adults?

Population

2,223 white men and women, aged 50-89 years, in the Rancho Bernardo cohort

Intervention

Non-insulin-dependent diabetes mellitus (NIDDM) or impaired glucose tolerance (IGT)

Comparator

Normal glucose tolerance

Outcome

Prevalence of ischemic heart disease (IHD) defined by Rose Questionnaire and resting electrocardiogram (ECG) according to the Minnesota Codesurrogate

Non-insulin-dependent diabetes mellitus is significantly associated with a higher prevalence of asymptomatic ischemic heart disease, as evidenced by resting ECG abnormalities, in older adults.

Cite This Study

Scheidt‐Nave et al. (1990) studied this question.

synapsesocial.com/papers/6a15de0f4718e7db3a52297e https://doi.org/10.1161/01.cir.81.3.899

Topics

Women and heart disease

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Resting electrocardiographic abnormalities suggestive of asymptomatic ischemic heart disease associated with non-insulin-dependent diabetes mellitus in a defined population.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Resting electrocardiographic abnormalities suggestive of asymptomatic ischemic heart disease associated with non-insulin-dependent diabetes mellitus in a defined population.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider