Key result
Intravenous ethinyl estradiol acutely attenuated abnormal coronary vasomotor responses to acetylcholine and increased basal coronary flow by 23.3% (P<0.01) in postmenopausal women.
Why the study?
Does intravenous ethinyl estradiol improve abnormal coronary vasomotor responses to acetylcholine in postmenopausal women?
RCT (n=48)
Does intravenous ethinyl estradiol improve abnormal coronary vasomotor responses to acetylcholine in postmenopausal women?
p-value: p=<0.01
Acute administration of ethinyl estradiol attenuates abnormal coronary vasomotor responses to acetylcholine and decreases basal coronary vasomotor tone in postmenopausal women, suggesting a mechanism for its cardioprotective effects.
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Supports vasomotor mechanism for estrogen cardioprotection in postmenopausal women; leaves open need for outcome trials.
Reís et al. (1994) conducted an RCT in Postmenopausal women (n=48). Ethinyl estradiol vs. Placebo was evaluated on Acetylcholine-induced changes in coronary flow, resistance, and cross-sectional area (p=<0.01). Intravenous ethinyl estradiol acutely attenuated abnormal coronary vasomotor responses to acetylcholine and increased basal coronary flow by 23.3% (P<0.01) in postmenopausal women.
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