January 1, 1994Circulation
Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women.
Key result
Intravenous ethinyl estradiol acutely attenuated abnormal coronary vasomotor responses to acetylcholine and increased basal coronary flow by 23.3% (P<0.01) in postmenopausal women.
Why the study?
Does intravenous ethinyl estradiol improve abnormal coronary vasomotor responses to acetylcholine in postmenopausal women?
Population
33 postmenopausal women
Comparison
Ethinyl estradiol administered intravenously vs Placebo and baseline measurements
Follow-up
15 minutes
Authors
Discussion
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Implication
Supports vasomotor mechanism for estrogen cardioprotection in postmenopausal women; leaves open need for outcome trials.
Key Points
- This research aims to evaluate the effects of ethinyl estradiol on coronary vasomotor responses to acetylcholine in postmenopausal women.
- 15 women received intravenous ethinyl estradiol (35 micrograms) to assess acetylcholine-induced vasomotor responses.
- 33 women were evaluated for changes in coronary flow, resistance, and cross-sectional area after either ethinyl estradiol or placebo administration.
- Data were collected on coronary vasomotor tone before and after treatment.
- After ethinyl estradiol administration, coronary flow increased by 23.3% (P < .01) and resistance decreased by 15.0% (P < .01).
- Seven women who previously had abnormal responses displayed normalized measures post-treatment with ethinyl estradiol (P < .01, P = .05, and P = .04 for flow, resistance, and area, respectively).
- Placebo treatment did not alter any parameters.
Study Design
Type
RCT (n=48)
Structured PICO
Does intravenous ethinyl estradiol improve abnormal coronary vasomotor responses to acetylcholine in postmenopausal women?
P
Population
33 postmenopausal women
I
Intervention
Ethinyl estradiol (35 micrograms) administered intravenously
C
Comparator
Placebo (for basal tone assessment) and baseline measurements (before ethinyl estradiol administration)
O
Outcome
Acetylcholine-induced changes in coronary flow, resistance, and cross-sectional areasurrogate
Main Result
p-value: p=<0.01
Acute administration of ethinyl estradiol attenuates abnormal coronary vasomotor responses to acetylcholine and decreases basal coronary vasomotor tone in postmenopausal women, suggesting a mechanism for its cardioprotective effects.
Cite This Study
Reís et al. (1994) conducted an RCT in Postmenopausal women (n=48). Ethinyl estradiol vs. Placebo was evaluated on Acetylcholine-induced changes in coronary flow, resistance, and cross-sectional area (p=<0.01). Intravenous ethinyl estradiol acutely attenuated abnormal coronary vasomotor responses to acetylcholine and increased basal coronary flow by 23.3% (P<0.01) in postmenopausal women.