Key result
Intensified antihypertensive treatment aiming for diastolic blood pressure ≤80 mmHg did not significantly reduce cardiovascular morbidity and mortality compared to unchanged therapy (28 vs 29 events).
Why the study?
Does intensified antihypertensive treatment aiming for diastolic blood pressure <= 80 mmHg reduce cardiovascular morbidity and mortality in well-treated hypertensive patients?
Population
2127 men and women with treated essential hypertension and diastolic blood pressure 90-100 mmHg on three…
Comparison
Intensified antihypertensive treatment aiming at… vs Unchanged antihypertensive therapy.
Design
RCT, Randomized to either intensified treatment or unchanged therapy
Follow-up
> 4 years
Authors
Loading...
No CV benefit from targeting DBP ≤80 mmHg in treated hypertension; reinforces standard targets without supporting further intensification.
RCT (n=2,127)
randomized
Yes
Does intensified antihypertensive treatment aiming for diastolic blood pressure <= 80 mmHg reduce cardiovascular morbidity and mortality in well-treated hypertensive patients?
Intensified antihypertensive treatment aiming for a diastolic blood pressure <= 80 mmHg did not significantly reduce cardiovascular morbidity and mortality compared to unchanged therapy over 4 years.
Lennart Hansson (1994) conducted an RCT in essential hypertension (n=2,127). Intensified antihypertensive treatment vs. Unchanged therapy was evaluated on Cardiovascular morbidity and mortality (strokes and myocardial infarcts). Intensified antihypertensive treatment aiming for diastolic blood pressure ≤80 mmHg did not significantly reduce cardiovascular morbidity and mortality compared to unchanged therapy (28 vs 29 events).