Why the study?
Does aerobic exercise training reduce the inducibility of ventricular tachycardia and fibrillation in healthy rats?
Population
30 male Sprague-Dawley rats (weight 250–300 g)
Comparison
Aerobic exercise training on a treadmill… vs Sedentary control group
Design
Preclinical, The rats were randomly divided into three groups
Follow-up
8 weeks
Key result
Aerobic exercise training for 8 weeks significantly reduced the probability of ventricular fibrillation induction to 6.7% compared to 26.1% in sedentary control rats.
Authors
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Aerobic exercise may reduce VF susceptibility via remodeling in rats; leaves open translation to human arrhythmia prevention.
Does aerobic exercise training reduce the inducibility of ventricular tachycardia and fibrillation in healthy rats?
Aerobic exercise in healthy rats induces intrinsic cardiac remodeling that reduces susceptibility to ventricular fibrillation and increases the electrical complexity of the heart.
Absolute Event Rate: 6.7% vs 26.1%
p-value: p=<0.05
Dor‐Haim et al. (2013) studied Healthy (Normal rats) (n=30). Aerobic exercise training vs. Sedentary control was evaluated on Probability of ventricular fibrillation (VF) induction (p=<0.05). Aerobic exercise training for 8 weeks significantly reduced the probability of ventricular fibrillation induction to 6.7% compared to 26.1% in sedentary control rats.