Key result
Circulating serine levels were significantly associated with left atrial reservoir strain (β 10.1) in community adults without symptomatic cardiovascular disease.
Why the study?
Do clinical factors and circulating metabolites associate with left atrial phasic function in community adults without overt cardiovascular disease?
Cross-Sectional (n=128)
Do clinical factors and circulating metabolites associate with left atrial phasic function in community adults without overt cardiovascular disease?
Effect estimate: β 10.1 (95% CI 2.0, 18.2)
p-value: p=0.015
Left atrial phasic function is differentially associated with age, heart rate, and specific circulating metabolites (e.g., serine, citrulline) in community adults prior to overt cardiovascular disease.
Serine–strain association should not change practice; leaves open longitudinal validation of metabolite roles in subclinical atrial remodeling.
Among community cohorts, associations between clinical and metabolite factors and complex left atrial (LA) phasic function assessed by cardiac magnetic resonance (CMR) feature tracking (FT) are unknown. Longitudinal LA strain comprising reservoir strain (εs), conduit strain (εe) and booster strain (εa) and their corresponding peak strain rates (SRs, SRe, SRa) were measured using CMR FT. Targeted mass spectrometry measured 83 circulating metabolites in serum. Sparse Principal Component Analysis was used for data reduction. Among community adults (n = 128, 41% female) (mean age: 70.5 ± 11.6 years), age was significantly associated with εs (β = -0.30, p < 0.0001), εe (β = -0.3, p < 0.0001), SRs (β = -0.02, p < 0.0001), SRe (β = 0.04, p < 0.0001) and SRe/SRa (β = -0.01, p = 0.012). In contrast, heart rate was significantly associated with εa (β = 0.1, p = 0.001) and SRa (β = -0.02, p < 0.0001). Serine was significantly associated with εs (β = 10.1, p = 0.015), SRs (β = 0.5, p = 0.033) and SRa (β = -0.9, p = 0.016). Citrulline was associated with εs (β = -4.0, p = 0.016), εa (β = -3.4, p = 0.002) and SRa (β = 0.4, p = 0.019). Valine was associated with ratio of SRe:SRa (β = -0.4, p = 0.039). Medium and long chain dicarboxyl carnitines were associated with εs (β = -0.6, p = 0.038). Phases of LA function were differentially associated with clinical and metabolite factors. Metabolite signals may be used to advance mechanistic understanding of LA disease in future studies.
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Koh et al. (2018) conducted a cross-sectional in Community adults without cardiovascular disease (n=128). Metabolomic profiling was evaluated on Association of serine with left atrial reservoir strain (εs) (β 10.1, 95% CI 2.0, 18.2, p=0.015). Circulating serine levels were significantly associated with left atrial reservoir strain (β 10.1) in community adults without symptomatic cardiovascular disease.
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