What question did this study set out to answer?

To synthesize knowledge on the chemical diversity, subcellular distribution, enzymatic generation, and effector interpretation of microtubule posttranslational modifications that constitute the tubulin code.

May 9, 2015Journal of Biological ChemistryOpen Access

Writing and Reading the Tubulin Code

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To synthesize knowledge on the chemical diversity, subcellular distribution, enzymatic generation, and effector interpretation of microtubule posttranslational modifications that constitute the tubulin code.
Reviewed biochemical and cell biological literature identifying posttranslational modification patterns across specialized microtubule structures.
Analyzed the enzymatic machinery responsible for writing modifications and the effector proteins that read and translate these chemical marks.
Tubulin posttranslational modifications generate discrete spatial patterns essential for the biogenesis and stabilization of specialized arrays, including spindles, cilia, neuronal processes, and platelets.
Enzymatic writers catalyze chemically distinct alterations that directly tune microtubule mechanical properties and selectively regulate recruitment of downstream effector complexes.

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Implication

Review reveals how diverse posttranslational modifications generate a tubulin code in eukaryotic cells, highlighting key mechanisms that regulate microtubule architecture and function.

Cite This Study

Yu et al. (2015) studied this question.

synapsesocial.com/papers/6a15ecc6557f83931ae3d1f2 https://doi.org/10.1074/jbc.r115.637447

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Implication

Review reveals how diverse posttranslational modifications generate a tubulin code in eukaryotic cells, highlighting key mechanisms that regulate microtubule architecture and function.

Writing and Reading the Tubulin Code

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Discussion

Implication

Cite This Study

Writing and Reading the Tubulin Code

Key Points

Discussion

Implication

Cite This Study

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