Key result
Taxol administration was associated with profound cardiac disturbances, including atrioventricular blocks, ventricular tachycardia, and ischemia, in 5% of patients (7 of 140).
Why the study?
Does taxol administration cause cardiac disturbances in cancer patients?
Population
140 patients who participated in four phase I and II studies of taxol, including patients with advanced and…
Design
Case_series
Authors
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May warrant cardiac monitoring during Taxol; leaves open true incidence and causality in larger populations.
Observational (n=140)
Does taxol administration cause cardiac disturbances in cancer patients?
Taxol administration is associated with potential cardiotoxicity, including bradycardia and more severe conduction or ischemic events in up to 5% of patients, warranting clinical caution.
Rowinsky et al. (1991) conducted an observational in Advanced and cisplatin-refractory ovarian carcinoma and other cancers (n=140). Taxol was evaluated on Profound cardiac disturbances (atrioventricular conduction blocks, left bundle branch block, ventricular tachycardia, and cardiac ischemia). Taxol administration was associated with profound cardiac disturbances, including atrioventricular blocks, ventricular tachycardia, and ischemia, in 5% of patients (7 of 140).
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