A full waveform inversion methodology using shear wave elastography effectively estimates both arterial elasticity and viscosity, as verified with synthetic data.
Does full waveform inversion using shear wave elastography accurately estimate arterial viscoelasticity?
A novel full waveform inversion methodology using shear wave elastography can simultaneously estimate arterial elasticity and viscosity, potentially providing a better indicator of arterial health.
Abstract Objective . Arterial viscosity is emerging as an important biomarker, in addition to the widely used arterial elasticity. This paper presents an approach to estimate arterial viscoelasticity using shear wave elastography (SWE). Approach . While dispersion characteristics are often used to estimate elasticity from SWE data, they are not sufficiently sensitive to viscosity. Driven by this, we develop a full waveform inversion (FWI) methodology, based on directly matching predicted and measured wall velocity in space and time, to simultaneously estimate both elasticity and viscosity. Specifically, we propose to minimize an objective function capturing the correlation between measured and predicted responses of the anterior wall of the artery. Results . The objective function is shown to be well-behaving (generally convex), leading us to effectively use gradient optimization to invert for both elasticity and viscosity. The resulting methodology is verified with synthetic data polluted with noise, leading to the conclusion that the proposed FWI is effective in estimating arterial viscoelasticity. Significance . Accurate estimation of arterial viscoelasticity, not just elasticity, provides a more precise characterization of arterial mechanical properties, potentially leading to a better indicator of arterial health.
Roy et al. (Wed,) conducted a other in Arterial viscoelasticity. Full waveform inversion (FWI) using shear wave elastography was evaluated on Estimation of arterial elasticity and viscosity. A full waveform inversion methodology using shear wave elastography effectively estimates both arterial elasticity and viscosity, as verified with synthetic data.