What does this research mean for the field?

Overexpression of protein kinase C-β2 in endothelial cells causes selective vascular insulin resistance, increases endothelin-1 expression, and increases the severity of atherosclerosis in the aorta by approximately 70%. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 12, 2013Circulation ResearchOpen Access

Induction of Vascular Insulin Resistance and Endothelin-1 Expression and Acceleration of Atherosclerosis by the Overexpression of Protein Kinase C-β Isoform in the Endothelium

Q: What is the clinical evidence from this study?

Study design: Other. Population: Atherosclerosis. Intervention: Overexpression of protein kinase C-β2 isoform vs. apoE-/- mice. Primary outcome: Severity of atherosclerosis in the aorta.

View Full Paper

Ask AI

Bookmark

Key result

Overexpression of protein kinase C-β2 in endothelial cells increased the severity of atherosclerosis in the aorta by ≈70% compared with apoE-/- mice.

Why the study?

Does overexpression of protein kinase C-β2 isoform in endothelial cells accelerate atherosclerosis in apoE-/- mice?

Population

apoE-/- mice on a Western diet

Comparison

Overexpression of protein kinase C-β2 isoform in… vs apoE-/- mice without protein kinase C-β2…

Design

Preclinical

Authors

QLQian LiWannan Medical College KPKyoungmin ParkJoslin Diabetes Center CLChen-Zhong LiChinese University of Hong Kong, Shenzhen

Discussion

Member takes

Implication

Should not change clinical practice; leaves open endothelial PKC-β2 as a therapeutic target in human atherosclerosis.

Structured PICO

Does overexpression of protein kinase C-β2 isoform in endothelial cells accelerate atherosclerosis in apoE-/- mice?

Population

apoE-/- mice on a Western diet

Intervention

Overexpression of protein kinase C-β2 isoform in endothelial cells [Tg(Prkcb)apoE-/-]

Comparator

apoE-/- mice without protein kinase C-β2 overexpression

Outcome

Severity of atherosclerosis in the aorta (measured by en face fat staining and plaque content)surrogate

Endothelial overexpression of protein kinase C-β2 accelerates atherosclerosis and induces vascular insulin resistance in a mouse model.

Cite This Study

Li et al. (2013) studied Atherosclerosis. Overexpression of protein kinase C-β2 isoform vs. apoE-/- mice was evaluated on Severity of atherosclerosis in the aorta. Overexpression of protein kinase C-β2 in endothelial cells increased the severity of atherosclerosis in the aorta by ≈70% compared with apoE-/- mice.

synapsesocial.com/papers/6a15f9eca6cdea2592d115d2 https://doi.org/10.1161/circresaha.113.301074

View Full Paper

Ask AI

Bookmark

Induction of Vascular Insulin Resistance and Endothelin-1 Expression and Acceleration of Atherosclerosis by the Overexpression of Protein Kinase C-β Isoform in the Endothelium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Induction of Vascular Insulin Resistance and Endothelin-1 Expression and Acceleration of Atherosclerosis by the Overexpression of Protein Kinase C-β Isoform in the Endothelium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider