What is the clinical evidence from this study?

Study design: Other. Population: G Protein-coupled Receptor Internalization.

What does this research mean for the field?

Dynamin is essential for the agonist-promoted sequestration of the beta2-adrenergic receptor via clathrin-coated vesicles, whereas the internalization of the angiotensin II type 1A receptor does not require dynamin, demonstrating that G protein-coupled receptors can utilize distinct endocytic pathways. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1996Journal of Biological ChemistryOpen Access

Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization

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Key result

Dynamin is essential for agonist-promoted sequestration of the beta2-adrenergic receptor via clathrin-coated vesicles, whereas AT1AR internalization does not require dynamin.

Population

Preclinical model studying G protein-coupled receptors

Design

Preclinical

Authors

JZJie ZhangYan'an University SFStephen S. G. FergusonUniversity of Ottawa LBLarry S. BarakDuke University

Discussion

Member takes

Implication

Indicates distinct GPCR endocytic routes; leaves open human cardiovascular translation from animal data.

Structured PICO

Population

Preclinical model studying G protein-coupled receptors (beta2-adrenergic receptor and angiotensin II type 1A receptor)

Intervention

Evaluation of dynamin and beta-arrestin function

Outcome

Agonist-promoted internalization (sequestration) of GPCRssurrogate

GPCRs can utilize distinct endocytic pathways, with beta-arrestins functioning as adaptor proteins that specifically target GPCRs for dynamin-dependent endocytosis via clathrin-coated vesicles.

Cite This Study

Zhang et al. (1996) studied G Protein-coupled Receptor Internalization. Dynamin is essential for agonist-promoted sequestration of the beta2-adrenergic receptor via clathrin-coated vesicles, whereas AT1AR internalization does not require dynamin.

synapsesocial.com/papers/6a15fa2fbdb7c25666524c7d https://doi.org/10.1074/jbc.271.31.18302

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Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider