Key result
Beta-arrestin inhibited the signaling function of beta ARK-phosphorylated beta-adrenergic receptors by more than 75 percent.
The discovery and cloning of beta-arrestin reveals its critical role as a cofactor with beta ARK in the homologous desensitization of beta-adrenergic receptors.
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Highlights beta-arrestin’s role in receptor regulation; extends beta ARK findings but leaves open therapeutic implications.
Lohse et al. (1990) studied this question. beta-arrestin was evaluated on signaling function of beta ARK-phosphorylated beta-adrenergic receptors. Beta-arrestin inhibited the signaling function of beta ARK-phosphorylated beta-adrenergic receptors by more than 75 percent.
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