Key result
High-resolution CT showed that lymphangitic carcinomatosis had greater involvement of the interlobular septa and subpleural interstitium compared to sarcoidosis and lymphoma.
Why the study?
Does High Resolution CT differentiate between sarcoidosis, lymphoma, and lymphangitic carcinoma based on interstitial involvement?
Observational (n=125)
Does High Resolution CT differentiate between sarcoidosis, lymphoma, and lymphangitic carcinoma based on interstitial involvement?
Answers are grounded in this paper and cite their sources.
High Resolution CT can help differentiate lymphangitic carcinomatosis from sarcoidosis and malignant lymphoma by showing greater involvement of the interlobular septa and subpleural interstitium.
PURPOSE: The purpose of this study was to determine distinguishing features of three diseases that are distributed along the lymphatics. METHOD: CT scans of 40 patients with lymphangitic carcinomatosis, 41 with sarcoidosis, and 44 with malignant lymphoma were retrospectively reviewed. We evaluated the degree of involvement of the interlobular septa, bronchovascular structures, subpleural interstitium, and other CT findings. RESULTS: The number of thickened interlobular septa and the extent of involvement of the subpleural interstitium in lymphangitic carcinomatosis were higher than those in sarcoidosis and malignant lymphoma (p<0.0001). Nodules of >1 cm in diameter were more often seen in malignant lymphoma (41.0%) than in the other two diseases (p < 0.001). Bilateral distribution was more common in sarcoidosis (100%) than in the others (p<0.001). CONCLUSION: The major difference among lymphangitic carcinomatosis, sarcoidosis, and malignant lymphoma is the greater involvement of the interlobular septa and subpleural interstitium in lymphangitic carcinomatosis than in either sarcoidosis or malignant lymphoma.
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Honda et al. (1999) conducted an observational in Lymphangitic carcinomatosis, sarcoidosis, and malignant lymphoma (n=125). High Resolution CT was evaluated on Degree of involvement of the interlobular septa, bronchovascular structures, and subpleural interstitium (p=<0.0001). High-resolution CT showed that lymphangitic carcinomatosis had greater involvement of the interlobular septa and subpleural interstitium compared to sarcoidosis and lymphoma.
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