Key result
Magnetic resonance imaging demonstrated that pulmonary hypertension patients exhibit pulmonary artery dilation (p<0.05) and decreased wall shear stress and kinetic energy (p<0.001).
Why the study?
Pulmonary hypertension is poorly characterized by non-invasive diagnostic imaging, despite being commonly associated with changes in vascular hemodynamics and pulmonary artery architectural remodeling.
Do MRI biomarkers of pulmonary artery remodeling and hemodynamics differ between patients with pulmonary hypertension and controls?
Case-Control (n=50)
Do MRI biomarkers of pulmonary artery remodeling and hemodynamics differ between patients with pulmonary hypertension and controls?
MRI-derived pulmonary artery remodeling and hemodynamic parameters show significant differences in patients with pulmonary hypertension, suggesting utility as non-invasive biomarkers.
MRI biomarkers may aid non-invasive pulmonary hypertension assessment; leaves open prospective validation before clinical use.
Poorly characterized by non-invasive diagnostic imaging techniques, pulmonary hypertension (PHT) is commonly associated with changes in vascular hemodynamics and remodeling of pulmonary artery architecture. These disease phenotypes represent potential biomarkers of interest in clinical environment. In this retrospective clinical study, 33 patients with pulmonary hypertension and seventeen controls were recruited. Architectural remodeling was characterized using 3D-contrast enhanced angiogram via the measurement of pulmonary artery diameters, bifurcation distances, and angles. Hemodynamics were characterized using 4D-flow magnetic resonance imaging (MRI) via wall shear stress, kinetic energy, vorticity, and directional flow dynamics. Parameters were compared using independent samples student’s t-tests. Correlational analysis was performed using Pearson’s correlation. PHT patients demonstrated dilation in the main and right branch of the pulmonary artery (p < 0.05). Furthermore, these patients also exhibited increases in bifurcation distances in the left and right pulmonary arteries (p < 0.05). Wall shear stress, maximum kinetic energy, and energy loss were decreased in the pulmonary artery (p < 0.001). Correlations were observed between peak velocities and right ventricle ejection fraction (r = 0.527, p < 0.05). These findings suggest that pulmonary artery remodeling and hemodynamic changes may possess clinical utility as MRI biomarkers for PHT.
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Hong et al. (2022) conducted a case-control in Pulmonary hypertension (n=50). Magnetic Resonance Imaging (3D-contrast enhanced angiogram and 4D-flow MRI) vs. Controls was evaluated on Pulmonary artery architectural remodeling and hemodynamics (p=<0.05). Magnetic resonance imaging demonstrated that pulmonary hypertension patients exhibit pulmonary artery dilation (p<0.05) and decreased wall shear stress and kinetic energy (p<0.001).
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