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February 27, 2023CureusOpen Access

GDMT rapidly improves LVEF by ~10% in a case of tachycardia-induced cardiomyopathy.

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Why the study?

Tachycardia-induced cardiomyopathy is a common cause of reversible cardiomyopathy, but data remain limited, particularly among young adults.

Does guideline-directed medical therapy improve left ventricular ejection fraction and heart rate in a young adult with tachycardia-induced cardiomyopathy?

Population

One 31-year-old woman with tachycardia and left ventricular dysfunction

Design

Case report

Follow-up

Four weeks

Key result

Guideline-directed medical therapy improved left ventricular ejection fraction from 45-50% to 55-60% within four weeks in a 31-year-old woman with tachycardia-induced cardiomyopathy.

Authors

OTOluwaremilekun Tolu-AkinnawoOOOghanim I OgwuAAAkintomiwa Akintunde

Discussion

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Member takes

Overview

Hypothesis-generating for rapid GDMT response in young adults with tachycardia-induced cardiomyopathy; prospective trials needed before practice change.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

Does guideline-directed medical therapy improve left ventricular ejection fraction and heart rate in a young adult with tachycardia-induced cardiomyopathy?

P
Population
31-year-old female with persistent tachycardia (124 beats per minute), mild global left ventricular hypokinesis, and systolic dysfunction (LVEF 45-50%)
I
Intervention
Guideline-directed medical therapy including beta blockers, angiotensin-converting enzyme inhibitors, and spironolactone
O
Outcome
Improvement in left ventricular ejection fraction and normalization of heart rate at 4 weekssurrogate

Early identification and treatment of tachycardia-induced cardiomyopathy with rate control and guideline-directed medical therapy can lead to rapid improvement in ventricular function.

Limitations

  • Limited data on the etiologies of tachycardia-induced cardiomyopathy in young adults

Cite This Study

Tolu-Akinnawo et al. (2023) conducted a case report in Tachycardia-induced cardiomyopathy (n=1). Guideline-directed medical therapy (beta blockers, ACE inhibitors, spironolactone) was evaluated on Left ventricular ejection fraction. Guideline-directed medical therapy improved left ventricular ejection fraction from 45-50% to 55-60% within four weeks in a 31-year-old woman with tachycardia-induced cardiomyopathy.

synapsesocial.com/papers/6a1602447cdde9fcee1275cehttps://doi.org/10.7759/cureus.35531
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ventricular remodeling during development and recovery from modified tachycardia-induced cardiomyopathy model1996 · 44 citations
  2. 2Pulmonary-Vein Isolation for Atrial Fibrillation in Patients with Heart Failure2008 · 775 citations
  3. 3Heart Failure and Sudden Death in Patients With Tachycardia-Induced Cardiomyopathy and Recurrent Tachycardia2004 · 387 citations
  4. 4Arrhythmia-Induced Cardiomyopathy2019 · 344 citations
  5. 5Tachycardia-induced cardiomyopathy2010 · 3 citations