What is the clinical evidence from this study?

Study design: Cohort. Population: Tachycardia-induced cardiomyopathy (n=101). Intervention: Age at TIC onset (per 1-year increase). Primary outcome: Left ventricular ejection fraction (LVEF) recovery (HR 0.912, 95% CI 0.863-0.964, p=0.001).

What does this research mean for the field?

Most children with tachycardia-induced cardiomyopathy achieve full recovery of left ventricular ejection fraction following rhythm control, with recovery predicted by age of onset, incessant tachycardia, and baseline left ventricular dilation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe the clinical characteristics, treatment approaches, and long-term prognosis of pediatric tachycardia-induced cardiomyopathy.

September 25, 2026BMC PediatricsOpen Access

Clinical management and prognosis of tachycardia-induced cardiomyopathy in children: a retrospective cohort study with 15-year single-center experience

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Key result

Older onset age in pediatric tachycardia-induced cardiomyopathy predicts ~9% slower LVEF recovery per year.

HR 0.912
95% CI 0.863-0.964
P=0.001
n=101

Why the study?

The clinical features and prognosis of pediatric tachycardia-induced cardiomyopathy were not well described in a large single-center cohort.

Population

101 children with tachycardia-induced cardiomyopathy at a tertiary children’s hospital in China

Comparison

Age groups and presence of incessant tachycardia in relation to recovery and ablation risk

Design

Retrospective cohort study

Follow-up

Median 34.0 months

Authors

XXXinyi XuRenji Hospital WFWan FengShanghai Jiao Tong University KWKai WangShanghai Jiao Tong University

Discussion

Member takes

Implication

May signal higher ablation risks in infants with TIC; hypothesis-generating and should not yet change practice.

Key Points

To describe the clinical characteristics, treatment approaches, and long-term prognosis of pediatric tachycardia-induced cardiomyopathy.
Retrospective review of 101 pediatric patients (58 boys; median age at TIC diagnosis of 1.4 years) treated at a tertiary children's hospital in China between 2009 and 2024.
Evaluation of clinical presentations, medical therapies, radiofrequency catheter ablation outcomes, adverse complications, and predictors of recovery over a median follow-up of 34.0 months (14.0–67.0).
Focal atrial tachycardia was the leading etiology (55.4%), and tachyarrhythmia achieved spontaneous resolution in 45.5% of patients (46/101), with age ≤ 1 year old conferring an 8.309-fold greater odds of spontaneous resolution.
Independent predictors of left ventricular ejection fraction recovery were age at TIC onset (HR: 0.912 per 1-year increase, 95% CI: 0.863–0.964, P = 0.001), incessant tachycardia (HR: 0.480, 95% CI: 0.310–0.743, P < 0.001), and baseline left ventricular end-diastolic dimension Z-score (HR: 0.828 per 1 SD increase, 95% CI: 0.700–0.980, P = 0.028).
Ablation-related adverse events occurred more frequently in children ≤ 1 year (66.7%, 2/3) than in those > 1 year (8.7%, 4/46; P = 0.04).

Study Design

Type

Cohort (n=101)

Multicenter

Structured PICO

Population

101 pediatric patients under 18 years of age with tachycardia-induced cardiomyopathy, followed for a median of 34.0 months.

Exposure

Rhythm control (antiarrhythmic drugs, catheter ablation, or surgery) and heart failure therapy (diuretics, MRAs, ACEIs, beta-blockers)

Outcome

Left ventricular ejection fraction (LVEF) recovery (≥ 55% or significant increase ≥ 20% from baseline) and spontaneous tachycardia resolutionsurrogate

Main Result

Hazard Ratio: 0.912 (95% CI 0.863–0.964)

p-value: p=0.001

In pediatric tachycardia-induced cardiomyopathy, most children recover fully after rhythm control, but older age, incessant tachycardia, and larger LV dilation predict slower recovery, while infants show higher spontaneous resolution but greater ablation risk.

Limitations

Retrospective design with potential selection bias, missing data, and recall bias
Single-center study limiting generalizability
Relatively small sample size limiting statistical power
Inability to determine arrhythmia duration due to initial presentation with symptomatic heart failure
High proportion of infants and limited use of intracardiac electrophysiological studies affecting diagnostic accuracy

Cite This Study

Xu et al. (2026) conducted a cohort in Tachycardia-induced cardiomyopathy (n=101). Age at TIC onset (per 1-year increase) was evaluated on Left ventricular ejection fraction (LVEF) recovery (HR 0.912, 95% CI 0.863-0.964, p=0.001). In pediatric patients with tachycardia-induced cardiomyopathy, older age at onset independently predicted slower left ventricular ejection fraction recovery (HR 0.912 per 1-year increase).

synapsesocial.com/papers/6ab60ecf406bf401c1467494 https://doi.org/10.1186/s12887-026-07712-7

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Clinical management and prognosis of tachycardia-induced cardiomyopathy in children: a retrospective cohort study with 15-year single-center experience

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Clinical management and prognosis of tachycardia-induced cardiomyopathy in children: a retrospective cohort study with 15-year single-center experience

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider