What question did this study set out to answer?

To develop an easily implementable, general multistage testing procedure for arbitrary parallel and serial gatekeeping problems without requiring the closed testing principle.

October 1, 2008Biometrical Journal

General Multistage Gatekeeping Procedures

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Authors

ADAlex DmitrienkoThe Childhood Acute Illness and Nutrition Network ATAjit C. TamhaneNorthwestern University BWBrian L. WiensLewis and Clark Pharmaceuticals (United States)

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Implication

Methodological analysis demonstrates general multistage gatekeeping procedures for arbitrary gatekeeping problems, highlighting increased statistical power over standard Bonferroni methods.

Key Points

To develop an easily implementable, general multistage testing procedure for arbitrary parallel and serial gatekeeping problems without requiring the closed testing principle.
Constructed a stepwise framework that carries forward Type I error rates from rejected hypotheses to subsequent ordered hypothesis families.
Introduced truncated, separable versions of standard multiple test procedures, including Holm, Hochberg, Fallback, and Dunnett methods.
Demonstrated the application and operational performance of the proposed multistage framework using a clinical trial example.
Eliminated the computational requirement to evaluate all nonempty intersections of hypotheses mandated by the closed testing principle.
Demonstrated that truncated separable procedures achieve greater statistical power than the standard Bonferroni multiple test procedure across multistage gatekeeping designs.

Cite This Study

Dmitrienko et al. (2008) studied this question.

synapsesocial.com/papers/6a160a68366ced26f1b567e7 https://doi.org/10.1002/bimj.200710464

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Implication

Methodological analysis demonstrates general multistage gatekeeping procedures for arbitrary gatekeeping problems, highlighting increased statistical power over standard Bonferroni methods.

General Multistage Gatekeeping Procedures

Discussion

Member takes

Implication

Key Points

Cite This Study

General Multistage Gatekeeping Procedures

Discussion

Member takes

Implication

Key Points

Cite This Study

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