What question did this study set out to answer?

To evaluate the prevalence of late ventricular potentials and ventricular arrhythmias in dilated and hypertrophic cardiomyopathies and determine their correlation with myocardial vulnerability and hemodynamic parameters.

November 1, 1988Pacing and Clinical Electrophysiology

Late Ventricular Potentials and Spontaneous and Induced Ventricular Arrhythmias in Dilated or Hypertrophic Cardiomyopathies. A Prospective Study About 83 Patients

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Why the study?

What is the prevalence of late ventricular potentials and ventricular arrhythmias, and how do they correlate with hemodynamic parameters and VT induction in patients with dilated or hypertrophic cardiomyopathy?

Population

83 patients with dilated cardiomyopathy or hypertrophic cardiomyopathy, and a control group of 32 normal…

Comparison

Electrophysiologic evaluation including 24-hour… vs Normal subjects and internal comparisons between…

Design

Cohort

Authors

JFJ P FauchierUniversité de Tours PCP CosnayCentre Hospitalier Universitaire de Tours BMB MoquetSorbonne Université

Discussion

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Implication

Supports distinct arrhythmic substrates in DCM versus HCM; leaves open late potentials' role in prospective risk stratification.

Key Points

To evaluate the prevalence of late ventricular potentials and ventricular arrhythmias in dilated and hypertrophic cardiomyopathies and determine their correlation with myocardial vulnerability and hemodynamic parameters.
Prospective evaluation of 83 patients with dilated cardiomyopathy (n = 56) or hypertrophic cardiomyopathy (n = 27) alongside 32 healthy controls.
Performed 24-hour Holter monitoring, exercise stress testing, noninvasive recording of late ventricular potentials, and programmed ventricular stimulation (n = 53).
Compared electrophysiologic parameters against echocardiographic dimensions and hemodynamic markers, including cardiac index and end-diastolic diameter.
Late ventricular potentials occurred in 26.8% (15/56) of dilated cardiomyopathy patients compared to 7.4% (2/27) of hypertrophic cases, reaching statistical significance versus healthy controls only in the dilated group.
Holter monitoring detected ventricular premature depolarizations in 80% of dilated cases (75% Lown grade ≥3) and 63% of hypertrophic cases (37% grade ≥3), while programmed stimulation induced sustained arrhythmias in 39.4% (13/33) and 10.0% (2/20), respectively.
Arrhythmias occurred largely independently of hemodynamic status, though dilated cardiomyopathy patients with late potentials and high-grade ectopy exhibited significantly lower cardiac index values.

Structured PICO

Population

83 patients with dilated cardiomyopathy (DCM, n=56) or hypertrophic cardiomyopathy (HCM, n=27), and a control group of 32 normal subjects.

Intervention

Electrophysiologic evaluation including 24-hour Holter monitoring, exercise stress testing, noninvasive recordings of late ventricular potentials (LVP), and programmed ventricular stimulation (PVS).

Comparator

Normal subjects (for LVP prevalence) and internal comparisons between DCM and HCM groups.

Outcome

Frequency of ventricular premature depolarisations (VPDs), correlation with myocardial vulnerability to ventricular tachycardia induction, and comparison of electrophysiologic and hemodynamic results.surrogate

Ventricular arrhythmias are frequent in both dilated and hypertrophic cardiomyopathies, but late ventricular potentials are significantly prevalent only in dilated cardiomyopathy.

Cite This Study

Fauchier et al. (1988) studied this question.

synapsesocial.com/papers/6a1612bc8ec422d49e949612 https://doi.org/10.1111/j.1540-8159.1988.tb06337.x

Topics

Hypertrophic cardiomyopathy

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Late Ventricular Potentials and Spontaneous and Induced Ventricular Arrhythmias in Dilated or Hypertrophic Cardiomyopathies. A Prospective Study About 83 Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Late Ventricular Potentials and Spontaneous and Induced Ventricular Arrhythmias in Dilated or Hypertrophic Cardiomyopathies. A Prospective Study About 83 Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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