Key result
In isolated rat hearts, 15-30 minutes of ischemia altered 39 protein spots correlating with ischemia duration, while changes after reperfusion did not correlate with ischemia duration.
Why the study?
Does the duration of ischemia affect the myocardial proteome in isolated rat hearts subjected to ischemia/reperfusion injury?
Does the duration of ischemia affect the myocardial proteome in isolated rat hearts subjected to ischemia/reperfusion injury?
Ischemia duration correlates with specific myocardial proteome changes in isolated rat hearts, but this correlation is altered upon reperfusion.
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Should not yet change clinical I/R management; hypothesis-generating for duration-specific proteomic signatures in isolated hearts.
Fert‐Bober et al. (2008) studied Ischemia/reperfusion injury. Ischemia/reperfusion vs. Ischemia without reperfusion was evaluated on Changes in protein levels (myocardial proteome). In isolated rat hearts, 15-30 minutes of ischemia altered 39 protein spots correlating with ischemia duration, while changes after reperfusion did not correlate with ischemia duration.
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