Key result
Pretreatment with the PKC activator PMA combined with adenosine significantly shortened the latency to develop K(ATP) current during metabolic inhibition from 15.1 to 5.5 minutes (P<0.02).
Population
Isolated rabbit ventricular myocytes
Comparison
Pretreatment with PKC activator phorbol… vs Metabolic inhibition alone, PMA alone, adenosine…
Design
Preclinical
Authors
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Provides mechanistic support for ischemic preconditioning; leaves open translation from animal models to clinical cardioprotection.
Absolute Event Rate: 5.5% vs 15.1%
p-value: p=< .02
Synergistic activation of PKC and adenosine receptors accelerates the opening of K(ATP) channels during metabolic inhibition, providing a mechanistic basis for ischemic preconditioning.
Liu et al. (1996) studied Ischemic preconditioning. Phorbol 12-myristate 13-acetate (PMA) and adenosine vs. Metabolic inhibition alone, PMA alone, or adenosine alone was evaluated on Latency to develop I(KATP) during metabolic inhibition (p=< .02). Pretreatment with the PKC activator PMA combined with adenosine significantly shortened the latency to develop K(ATP) current during metabolic inhibition from 15.1 to 5.5 minutes (P<0.02).
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