September 1, 1990AJP Heart and Circulatory Physiology

Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes

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Population

Neonatal rat ventricular myocytes

Comparison

Application of intracellular GTP with… vs Intracellular ATP alone

Design

Preclinical

Authors

GKGlenn E. KirschElectrophysiology JCJuan CodinaElectrophysiology LBLutz BirnbaumerElectrophysiology

Discussion

Member takes

Implication

Supports Gi-mediated adenosine activation of KATP channels in rat myocytes; leaves open relevance to human ischemia.

Structured PICO

Population

Neonatal rat ventricular myocytes

Intervention

Application of intracellular GTP with extracellular adenosine or N6-cyclohexyladenosine, and preactivated G alpha subunits (alpha i1, alpha i2, alpha i3)

Comparator

Intracellular ATP alone

Outcome

Tolbutamide-sensitive K+[ATP] channel activitysurrogate

K+[ATP] channels in rat ventricular myocytes are coupled to adenosine receptors via Gi alpha proteins through a membrane-delimited pathway, which may be important for channel activation during ischemia.

Cite This Study

Kirsch et al. (1990) studied this question.

synapsesocial.com/papers/6a70c7ae87f921057127e23d https://doi.org/10.1152/ajpheart.1990.259.3.h820

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Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider