Why the study?
Does early onset unipolar depression compared to late onset unipolar depression associate with higher familial morbidity risks for depression, alcoholism, and sociopathy?
Population
106 probands with unipolar depression consecutively admitted to the New York State Psychiatric Institute…
Comparison
Early onset unipolar depression (before age 40) vs Late onset unipolar depression (after age 40)
Design
Cross-sectional
Authors
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Supports two unipolar depression subtypes via familial patterns; hypothesis-generating and should not yet change practice.
Does early onset unipolar depression compared to late onset unipolar depression associate with higher familial morbidity risks for depression, alcoholism, and sociopathy?
Early onset unipolar depression is associated with higher familial morbidity for depression, alcoholism, and sociopathy compared to late onset, supporting the concept of two distinct subtypes of the illness.
Mendlewicz et al. (1981) studied this question.
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