What question did this study set out to answer?

Synthesize current evidence regarding the reciprocal interactions between glial-mediated neuroinflammatory responses and calcium homeostasis dysregulation in Alzheimer disease pathogenesis.

September 1, 2022CellsOpen Access

Role of Microglia and Astrocytes in Alzheimer’s Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

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Authors

GBGiulia Di BenedettoUniversity of Catania CBChiara BurgalettoUniversity of Catania CBCarlo Maria BellancaUniversity of Cagliari

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Implication

Narrative review uncovers interactions between glial inflammation and calcium dysregulation in Alzheimer disease, highlighting aberrant signaling as a key driver of neurodegeneration.

Key Points

Synthesize current evidence regarding the reciprocal interactions between glial-mediated neuroinflammatory responses and calcium homeostasis dysregulation in Alzheimer disease pathogenesis.
Narrative synthesis of molecular and cellular studies evaluating glial cell biology, neuroinflammation, and calcium signaling throughout the Alzheimer disease continuum.
Aberrant calcium signaling in astrocytes and microglia promotes and sustains chronic neuroinflammatory processes in the Alzheimer disease brain.
Glial-mediated inflammatory responses reciprocally disrupt neuronal calcium homeostasis, accelerating neurodegeneration and functional cognitive decline.

Cite This Study

Benedetto et al. (2022) studied this question.

synapsesocial.com/papers/6a162b22512cb4f7828e900a https://doi.org/10.3390/cells11172728

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Implication

Narrative review uncovers interactions between glial inflammation and calcium dysregulation in Alzheimer disease, highlighting aberrant signaling as a key driver of neurodegeneration.

Role of Microglia and Astrocytes in Alzheimer’s Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

Discussion

Member takes

Implication

Key Points

Cite This Study

Role of Microglia and Astrocytes in Alzheimer’s Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

Discussion

Member takes

Implication

Key Points

Cite This Study

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