Key result
High risk pregnancies were associated with significantly higher total creatine kinase activity in cord blood compared to pregnancies without risk (166.28 vs 126.90 U/L).
Why the study?
Does high-risk pregnancy increase cord blood total CK, CK-MB, and CK-BB activity in full-term newborns?
Observational (n=100)
No
Does high-risk pregnancy increase cord blood total CK, CK-MB, and CK-BB activity in full-term newborns?
High-risk pregnancies are associated with significantly elevated cord blood total CK, CK-MB, and CK-BB activities in full-term newborns, suggesting increased perinatal stress.
Background: Creatine kinase (CK) is a key enzyme of energy metabolism, especially in muscle tissue. CK has two polypeptide chains of M and B, and three isomers, CK-BB, CK-MB and CK- MM. In some conditions like acute myocardial infarction and neuromuscular disorders, increased CK activity is used as a part of diagnosis. CK can also be elevated in absence of neuromuscular diseases or cardiac injury, such as strenuous exercise, intramuscular injections etc. Several reports indicate elevated activity of serum CK in the maternal blood during child birth. This study aimed to correlate total CK and its isoenzymes activity in the cord blood with high risk pregnancies.Methods: This was a Prospective observational study conducted in the Obstetrics and Biochemistry Department of Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India. Cord blood of 100 full term newborns was collected and serum was analyzed for total CK and its isoenzymes activity by modified IFCC method. SPSS software was used in data analysis.Results: CK-total and its isoenzymes (CK-MB, CK-BB) activities were observed higher in cases with risk as compared to those without risk. Total CK activity was observed independent while CK-MB and CK-BB were found dependent on different risk factors like pregnancy induced hypertension and fetal distress etc.Conclusions: Present study revealed that high risk pregnancies are associated with increased total CK, CK-MB as well as CK-BB activity.
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Khan et al. (2017) conducted an observational in High risk pregnancy (n=100). High risk pregnancy vs. No risk pregnancy was evaluated on Total creatine kinase (CK) activity in cord blood (U/L) (p=<0.001). High risk pregnancies were associated with significantly higher total creatine kinase activity in cord blood compared to pregnancies without risk (166.28 vs 126.90 U/L).
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