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May 4, 2023Expert Review of Respiratory Medicine

Management of pulmonary arterial hypertension during pregnancy

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Key result

Pregnancy in PAH is linked to high maternal mortality and should generally be avoided.

Why the study?

Pregnancy carries high maternal mortality in PAH, but the number of women with PAH wishing to become pregnant is increasing despite current contraindication recommendations.

Design

Review

Authors

KKKaushiga KrishnathasanRoyal Brompton HospitalACAndrew ConstantineAdult Congenital Heart DiseaseIRIsma RafiqPediatric / Congenital Cardiology

Discussion

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Implication

Strengthens counseling to avoid pregnancy in PAH; leaves open optimal multidisciplinary protocols pending prospective data.

Structured PICO

P
Population
Women with pulmonary arterial hypertension (PAH) who are pregnant or of childbearing potential
I
Intervention
Expert multidisciplinary management, preconception counseling, contraception, and optimization of PAH therapies

Pregnancy in PAH carries high maternal mortality and should generally be avoided, but requires expert multidisciplinary management if it occurs.

Cite This Study

Krishnathasan et al. (2023) conducted a review in Pulmonary arterial hypertension during pregnancy. Multidisciplinary management and preconception counseling was evaluated. Pregnancy in patients with pulmonary arterial hypertension is associated with high maternal mortality and should generally be avoided, requiring expert multidisciplinary management if it occurs.

synapsesocial.com/papers/6a16348da75dcd943e938329https://doi.org/10.1080/17476348.2023.2210838
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The right ventricle in pulmonary arterial hypertension2014 · 272 citations
  2. 2Pregnancy and pulmonary hypertension: a practical approach to management2013 · 49 citations
  3. 3Improved survival in pregnancy and pulmonary hypertension using a multiprofessional approach2010 · 210 citations
  4. 4Pulmonary Hypertension and Pregnancy Outcomes: Data from the Registry Of Pregnancy and Cardiac Disease (ROPAC) of the European Society of Cardiology2016 · 278 citations
  5. 5Pulmonary Hypertension and Pregnancy Outcomes: Insights From the National Inpatient Sample2017 · 94 citations