Pulmonary embolism-related mortality rates increased significantly among individuals younger than 70 years in the US between 1999 and 2019, with the highest relative increase (APC 4.1%) in those aged 25-39 years.
Observational
PE-related mortality has been increasing in the US among individuals younger than 70 years, particularly in the 25-39 age group, highlighting a concerning epidemiological trend.
Estimación del efecto: APC 4.1 (95% CI 1.8 to 6.5)
Tasa de eventos absoluta: 2.4% vs 2%
Introduction: Acute pulmonary embolism (PE) is a major cause of mortality in the United States. Recent reports indicate that PE-related mortality rates have increased among individuals younger than 65 years old. It remains unclear whether this increase in PE-related mortality is evenly distributed. A narrowly focused and clinically meaningful age group analysis is necessary. Methods: Death certificate data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database were examined to determine all-cause PE mortality trends from 1999 to 2019 among adults 25-39, 40-54, 55-69, 70-84, and ≥85 years old. The crude death rates for individual years and annual percentage change (APC) were calculated to determine trends. Results: PE-related mortality rates increased among those 25-39, 40-54, and 55-69. Among individuals 25-39 years old, death rate increased from 1.8 to 2.0 (APC 0.7 95% confidence interval (CI) 0.2 to 1.1) between 1999 and 2014 and continued to increase from 2.0 to 2.4 (APC 4.1 95% CI 1.8 to 6.5) between 2014 and 2019. Among those 40-54 years old, the crude death rate increased from 5.7 to 7.5 (APC 2.0 95% CI, 1.6 to 2.5) between 2007 and 2019. Among those 55-69 years old the crude death rate increased from 15.6 to 18.5 (APC 2.2 95% CI, 1.9 to 2.5) between 2010 and 2019. Recent death rates decreased or plateaued among individuals older than 70. Conclusions: Individuals younger than 70 years had increase in PE-related mortality between 1999 and 2019 with marked increase among those 25-39 years old.
Cash et al. (Sat,) conducted a observational in Pulmonary embolism mortality. Observation of temporal trends vs. Historical rates was evaluated on Annual percentage change (APC) in crude PE death rate among individuals aged 25-39 years (2014-2019) (APC 4.1, 95% CI 1.8 to 6.5). Pulmonary embolism-related mortality rates increased significantly among individuals younger than 70 years in the US between 1999 and 2019, with the highest relative increase (APC 4.1%) in those aged 25-39 years.