What question did this study set out to answer?

To review the cell biology, intracellular trafficking, and proteolytic processing of the amyloid beta-protein precursor and evaluate its role in the pathogenesis of Alzheimer's disease.

November 1, 1994Annual Review of Cell Biology

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

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Authors

DSDennis J. SelkoeBrigham and Women's Hospital

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Implication

Narrative review details amyloid precursor protein trafficking and proteolytic processing in cell models, highlighting mechanisms driving Alzheimer disease pathogenesis.

Key Points

To review the cell biology, intracellular trafficking, and proteolytic processing of the amyloid beta-protein precursor and evaluate its role in the pathogenesis of Alzheimer's disease.
Synthesized biochemical, genetic, and histopathological literature analyzing amyloid beta (Aβ) generation from the amyloid precursor protein (APP).
Evaluated experimental cell biology studies investigating APP trafficking in polarized cells and regulation by first messengers.
Demonstrated that alternative proteolytic processing pathways determine whether benign fragments or pathogenic Aβ peptides are generated.
Identified genetic mutations linked to familial Alzheimer's disease that directly alter APP processing and promote Aβ accumulation.
Characterized the secretory sorting, membrane trafficking, and messenger-mediated signaling pathways controlling APP cleavage.

Cite This Study

Dennis J. Selkoe (1994) studied this question.

synapsesocial.com/papers/6a163f7ded257bd69ec5196a https://doi.org/10.1146/annurev.cb.10.110194.002105

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Implication

Narrative review details amyloid precursor protein trafficking and proteolytic processing in cell models, highlighting mechanisms driving Alzheimer disease pathogenesis.

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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