Key result
Cardiac macrophages and secreted inflammatory cytokines drive ventricular arrhythmia initiation and progression.
Why the study?
Recent clinical studies have indicated that macrophages and macrophage-secreted inflammatory cytokines are closely related to ventricular arrhythmias.
This review synthesizes evidence on the mechanistic role of cardiac macrophages and inflammatory cytokines in ventricular arrhythmogenesis, suggesting potential immunomodulatory targets for arrhythmia management.
May identify immunomodulatory targets for ventricular arrhythmias; hypothesis-generating and should not change practice without trials.
In the heart, cardiac macrophages have widespread biological functions, including roles in antigen presentation, phagocytosis, and immunoregulation, through the formation of diverse cytokines and growth factors; thus, these cells play an active role in tissue repair after heart injury. Recent clinical studies have indicated that macrophages or elevated inflammatory cytokines secreted by macrophages are closely related to ventricular arrhythmias (VAs). This review describes the role of macrophages and macrophage-secreted inflammatory cytokines in ventricular arrhythmogenesis.
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Chen et al. (2020) conducted a review in Ventricular Arrhythmias. Cardiac macrophages and their secreted inflammatory cytokines, such as IL-1β, TNF-α, IL-6, and MMP-9, play a critical role in the initiation and progression of ventricular arrhythmias.
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