Key result
Review explores multiscale muscle physiology dynamics from atom to organ sparked by sliding filament theory.
Why the study?
Connecting structural and functional muscle properties across spatiotemporal scales remains a major challenge despite decades of research following the sliding filament theory.
This review provides a multiscale perspective on muscle physiology research stemming from the sliding filament theory, relevant for applications from biomimetics to treating heart disease.
Answers are grounded in this paper and cite their sources.
May inform cardiac muscle modeling in research; leaves open clinical translation to heart disease therapies.
Two groundbreaking papers published in 1954 laid out the theory of the mechanism of muscle contraction based on force-generating interactions between myofilaments in the sarcomere that cause filaments to slide past one another during muscle contraction. The succeeding decades of research in muscle physiology have revealed a unifying interest: to understand the multiscale processes-from atom to organ-that govern muscle function. Such an understanding would have profound consequences for a vast array of applications, from developing new biomimetic technologies to treating heart disease. However, connecting structural and functional properties that are relevant at one spatiotemporal scale to those that are relevant at other scales remains a great challenge. Through a lens of multiscale dynamics, we review in this article current and historical research in muscle physiology sparked by the sliding filament theory.
No takes yet. Share an insight, caveat, or question.
Powers et al. (2021) conducted a review in Muscle physiology. This review explores current and historical research in muscle physiology sparked by the sliding filament theory, focusing on the multiscale dynamics from atom to organ.
Synapse has enriched 10 related papers. Consider them for comparative context: