Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 21, 1997Circulation

Prediction of Transition to Chronic Atrial Fibrillation in Patients With Paroxysmal Atrial Fibrillation by Signal- Averaged Electrocardiography

View Full Paper
Ask AI
Bookmark
Share

Key result

Abnormal P-wave-triggered signal-averaged ECG predicted a significantly higher rate of transition to chronic atrial fibrillation compared to normal P-SAE (43% vs 4%, P<0.0001).

Why the study?

Does P-wave-triggered signal-averaged ECG predict the transition to chronic atrial fibrillation in patients with paroxysmal atrial fibrillation?

Population

122 consecutive patients with paroxysmal atrial fibrillation (PAF)

Comparison

P-wave-triggered signal-averaged ECG abnormality vs Normal P-SAE (Ad < 145 ms or LP30 >= 3.0 microV)

Design

Cohort

Follow-up

mean 26+/-12 months

Authors

YAYasushi AbeNihon UniversityMFMasatake FukunamiOsaka Prefectural Medical CenterTYTakahisa YamadaOsaka Prefectural Medical Center

Discussion

Loading...

Member takes

Overview

May aid progression risk stratification in paroxysmal AF; leaves open need for prospective validation before clinical use.

Key Points

  • To determine if P-wave-triggered signal-averaged ECG (P-SAE) can predict the transition from paroxysmal to chronic atrial fibrillation.
  • Followed 122 patients with paroxysmal atrial fibrillation using P-SAE, echocardiography, and 24-hour Holter monitoring.
  • Measured duration (Ad) and root-mean-square voltage (LP30) of filtered P waves in P-SAE.
  • Defined abnormal P-SAE as Ad ≥145 ms and LP30 < 3.0 microV.
  • 19% of patients had abnormal P-SAE, with 43% transitioning to chronic atrial fibrillation during follow-up.
  • Only 4% of patients without abnormal P-SAE transitioned to chronic atrial fibrillation.
  • Significant association of transition to chronic atrial fibrillation with Ad (chi2=8.6, P=.003) and LP30 (chi2=5.1, P=.02).

Study Design

Type

Cohort (n=122)

Structured PICO

Does P-wave-triggered signal-averaged ECG predict the transition to chronic atrial fibrillation in patients with paroxysmal atrial fibrillation?

P
Population
122 consecutive patients with paroxysmal atrial fibrillation (PAF)
I
Intervention
P-wave-triggered signal-averaged ECG (P-SAE) abnormality (defined as filtered P wave duration [Ad] >= 145 ms and root-mean-square voltage for the last 30 ms [LP30] < 3.0 microV)
C
Comparator
Normal P-SAE (Ad < 145 ms or LP30 >= 3.0 microV)
O
Outcome
Transition to chronic atrial fibrillation (CAF)hard clinical

Main Result

Absolute Event Rate: 43% vs 4%

p-value: p=<.0001

P-wave-triggered signal-averaged ECG abnormalities strongly predict the transition from paroxysmal to chronic atrial fibrillation.

Cite This Study

Abe et al. (1997) conducted a cohort in Paroxysmal atrial fibrillation (n=122). P-wave-triggered signal-averaged ECG (P-SAE) abnormality vs. No P-SAE abnormality was evaluated on Transition to chronic atrial fibrillation (CAF) (p=<.0001). Abnormal P-wave-triggered signal-averaged ECG predicted a significantly higher rate of transition to chronic atrial fibrillation compared to normal P-SAE (43% vs 4%, P<0.0001).

synapsesocial.com/papers/6a1656817ec94de605d96976https://doi.org/10.1161/01.cir.96.8.2612
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Detection of patients at risk for paroxysmal atrial fibrillation during sinus rhythm by P wave-triggered signal-averaged electrocardiogram.1991 · 355 citations
  2. 2Epidemiologic Features of Chronic Atrial Fibrillation1982 · 2,340 citations
  3. 3Clinical features of paroxysmal atrial fibrillation an observation of 94 patients.1981 · 124 citations
  4. 4ATRIAL FIBRILLATION AND STROKE IN ELDERLY HOSPITALIZED PATIENTS1986 · 70 citations
  5. 5Electrocardiographic Findings Among the Adult Population of a Total Natural Community, Tecumseh, Michigan1965 · 348 citations