Passive smoking and risk of coronary heart disease and stroke: prospective study with cotinine measurement
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Key result
Passive exposure to tobacco smoke (cotinine 2.8-14.0 ng/ml) was associated with an increased risk of coronary heart disease compared to low exposure (HR 1.57; 95% CI 1.08-2.28).
Why the study?
Does passive smoking exposure (measured by serum cotinine) increase the risk of major coronary heart disease and stroke in non-smoking men?
Population
4,729 men in 18 towns, with analysis focused on 2,105 non-smoking men with cotinine < 14.1 ng/ml
Comparison
Higher passive smoking exposure vs Lowest passive smoking exposure
Design
Cohort
Follow-up
20 years
Authors
Discussion
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Member takes
Implication
May support avoiding passive smoke exposure; extends self-report data with objective cotinine but leaves causality open.
Study Design
Type
Cohort (n=4,729)
Multicenter
Yes
Structured PICO
Does passive smoking exposure (measured by serum cotinine) increase the risk of major coronary heart disease and stroke in non-smoking men?
P
Population
4,729 men in 18 towns (British regional heart study), with analysis focused on 2,105 non-smoking men with cotinine < 14.1 ng/ml
I
Intervention
Higher passive smoking exposure (serum cotinine 0.8-14.0 ng/ml)
C
Comparator
Lowest passive smoking exposure (serum cotinine ≤ 0.7 ng/ml)
O
Outcome
Major coronary heart disease and stroke events (fatal and non-fatal) during 20 years of follow uphard clinical
Main Result
Effect estimate: HR 1.57 (95% CI 1.08-2.28)
Passive smoking, as objectively measured by serum cotinine, is associated with a significantly increased risk of coronary heart disease in non-smoking men.
Cite This Study
Whincup et al. (2004) conducted a cohort in Coronary heart disease and stroke (n=4,729). Passive smoking (serum cotinine concentration) vs. First quarter (≤0.7 ng/ml) was evaluated on Major coronary heart disease and stroke events (fatal and non-fatal) (HR 1.57, 95% CI 1.08-2.28). Passive exposure to tobacco smoke (cotinine 2.8-14.0 ng/ml) was associated with an increased risk of coronary heart disease compared to low exposure (HR 1.57; 95% CI 1.08-2.28).
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