Key result
Blood cardioplegia compared to crystalloid cardioplegia showed no significant intergroup differences in the occurrence of immediate postoperative rhythm disturbances after coronary artery bypass grafting.
Why the study?
Does blood cardioplegia reduce postoperative rhythm disturbances compared to crystalloid cardioplegia in patients undergoing CABG?
RCT (n=100)
Randomized
Does blood cardioplegia reduce postoperative rhythm disturbances compared to crystalloid cardioplegia in patients undergoing CABG?
Blood and crystalloid cardioplegia are associated with similar rates of immediate postoperative rhythm disturbances in CABG patients, likely driven by ischemia or incomplete myocardial protection.
Answers are grounded in this paper and cite their sources.
Either cardioplegia solution is acceptable for CABG rhythm safety; confirms equivalence in this RCT.
One hundred consecutive patients scheduled for coronary artery bypass grafting were randomized to receive either blood or crystalloid cardioplegia. Successful Holter monitoring for rhythm disturbances was done before and immediately after the operation in 83 cases. With both modes of cardioplegia there were increases in the occurrence of rhythm disturbances postoperatively. The increases were mostly statistically significant. There was no intergroup differences in the occurrence of arrhythmias. The association between these disturbances and cross-clamp times, myocardial temperatures during cross-clamping, myocardial fibrillation times during and after cross-clamping, CK-MB values and perioperative infarction all indicated ischaemia or incomplete myocardial protection as a major cause of the immediate postoperative rhythm disturbances.
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Pehkonen et al. (1995) conducted an RCT in Coronary artery bypass grafting (n=100). Blood cardioplegia vs. Crystalloid cardioplegia was evaluated on Occurrence of rhythm disturbances postoperatively. Blood cardioplegia compared to crystalloid cardioplegia showed no significant intergroup differences in the occurrence of immediate postoperative rhythm disturbances after coronary artery bypass grafting.
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