What question did this study set out to answer?

To evaluate the role of dietary fibre in modulating gut microbiota dysbiosis, short-chain fatty acid levels, and glycaemic parameters in patients with type 2 diabetes.

October 23, 2020NutrientsOpen Access

The Role of Dietary Fibre in Modulating Gut Microbiota Dysbiosis in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

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Authors

OOOmorogieva OjoSouth London and Maudsley NHS Foundation Trust OOOmorogieva OjoSouth London and Maudsley NHS Foundation Trust QFQianqian FengSecond Affiliated Hospital of Zhejiang University

Discussion

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Implication

Systematic review and meta-analysis demonstrates dietary fibre increases Bifidobacterium and lowers glycated haemoglobin in type 2 diabetes, indicating microbial pathways aid glycaemic control.

Key Points

To evaluate the role of dietary fibre in modulating gut microbiota dysbiosis, short-chain fatty acid levels, and glycaemic parameters in patients with type 2 diabetes.
Systematic review and meta-analysis of randomised controlled trials conducted following the PRISMA framework across EBSCOHost, EMBASE, and Google Scholar up to August 5, 2020.
Identified and synthesized data from 9 randomised controlled trials comparing dietary fibre interventions with placebo controls in patients with type 2 diabetes.
Dietary fibre significantly increased the relative abundance of Bifidobacterium (mean difference 0.72, 95% CI 0.56 to 0.89; p < 0.01) and total short-chain fatty acids (standardised mean difference 0.5, 95% CI 0.08 to 0.91; p = 0.02) compared with placebo.
Glycated haemoglobin improved significantly with dietary fibre (mean difference −0.18, 95% CI −0.29 to −0.06; p = 0.02), whereas differences in individual short-chain fatty acids, fasting blood glucose, HOMA-IR, and adverse events were non-significant (p > 0.05).

Cite This Study

Ojo et al. (2020) studied this question.

synapsesocial.com/papers/6a16632da8d6c30f746237f1 https://doi.org/10.3390/nu12113239

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Implication

Systematic review and meta-analysis demonstrates dietary fibre increases Bifidobacterium and lowers glycated haemoglobin in type 2 diabetes, indicating microbial pathways aid glycaemic control.

The Role of Dietary Fibre in Modulating Gut Microbiota Dysbiosis in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Discussion

Member takes

Implication

Key Points

Cite This Study

The Role of Dietary Fibre in Modulating Gut Microbiota Dysbiosis in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Discussion

Member takes

Implication

Key Points

Cite This Study

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