What does this research mean for the field?

The first postextrasystolic beat exhibits improved hemodynamics that compensates for extrasystole-induced depression by an average of 60%, driven independently by ventricular blood volume (Starling's effect) and ventricular contractility. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

January 1, 1970Japanese Circulation JournalOpen Access

Experimental Studies on Myocardial Contractility and Hemodynamics in Extrasystoles

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Population

Dogs (experimental model)

Comparison

Experimentally induced extrasystoles with a… vs Pre-extrasystolic beat of the basic rhythm

Design

Preclinical

Authors

HTHideo TakadaNational Archives and Records Administration STShozo TakeuchiNagoya University KAKoichi AndōTokyo Metropolitan University

Discussion

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Implication

Hypothesis-generating in canines; leaves open whether postextrasystolic potentiation offsets extrasystolic effects in humans.

Structured PICO

Population

Dogs (experimental model)

Intervention

Experimentally induced extrasystoles with a fully compensated pause

Comparator

Pre-extrasystolic beat of the basic rhythm

Outcome

Myocardial contractility and hemodynamicssurrogate

In a canine model, postextrasystolic potentiation provides a positive inotropic effect that partially compensates for the hemodynamic depression caused by extrasystoles.

Cite This Study

Takada et al. (1970) studied this question.

synapsesocial.com/papers/6a1665615c9fbf26ee4c51db https://doi.org/10.1253/jcj.34.419

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Experimental Studies on Myocardial Contractility and Hemodynamics in Extrasystoles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Experimental Studies on Myocardial Contractility and Hemodynamics in Extrasystoles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider