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Starling's law of the heart has been studied in the dog with a complete circulation with the continuous registration of cardiac output, and atrial and arterial pressures. From this data ventricular function curves were constructed. In any given physiologic state there was a consistent and reproducible correlation between atrial pressure and ventricular stroke work on the same side. The classically conceived descending limb did not occur in the normal heart. The concept of a family of Starling or ventricular function curves adds a third dimension to the adaptive capacity of the heart as put forth by Frank and Starling.
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Stanley J. Sarnoff
Washington University in St. Louis
Erik Berglund
Karolinska Institutet
Circulation
Harvard University
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Sarnoff et al. (Sat,) studied this question.
synapsesocial.com/papers/6a1039e892676d5461fdc07e — DOI: https://doi.org/10.1161/01.cir.9.5.706
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