Key result
Adenosine (10 microM) significantly reduced upstroke velocity and action potential amplitude, depressed contractile force, and abolished abnormal automatic rhythms in isolated human atrial fibers.
Adenosine exerts depressant electrophysiological effects on human atrial fibers, suggesting it may abolish abnormal automatic rhythms and triggered activity in human atria.
Adenosine may suppress atrial tachyarrhythmias via direct effects; leaves open in vivo translation to patients.
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Wang et al. (1991) studied Patients undergoing corrective cardiac surgery (n=25). Adenosine vs. Baseline / DPSPX was evaluated on Action potential characteristics and contractile force. Adenosine (10 microM) significantly reduced upstroke velocity and action potential amplitude, depressed contractile force, and abolished abnormal automatic rhythms in isolated human atrial fibers.
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