Key result
CMR reveals severely impaired global peak circumferential strain in NICM patients with ventricular arrhythmias.
Why the study?
The study sought to investigate the feasibility of using CMR-FT to analyze LV strain and strain rate in patients with NIDCM combined with VAs, and to evaluate correlations with LVEF.
Does cardiovascular magnetic resonance feature tracking (CMR-FT) accurately assess LV myocardial deformation and correlate with LVEF in patients with non-ischemic dilated cardiomyopathy combined with ventricular arrhythmias?
Case-Control (n=59)
No
Does cardiovascular magnetic resonance feature tracking (CMR-FT) accurately assess LV myocardial deformation and correlate with LVEF in patients with non-ischemic dilated cardiomyopathy combined with ventricular arrhythmias?
Absolute Event Rate: -5.99% vs -21.75%
p-value: p=<0.001
CMR-FT is a feasible technique for assessing LV myocardial deformation in patients with NIDCM and ventricular arrhythmias, with global peak circumferential strain showing a strong negative correlation with LVEF.
May support CMR-FT strain for deformation assessment in NIDCM; hypothesis-generating for arrhythmia risk and requires prospective validation.
This study investigated the feasibility of using cardiovascular magnetic resonance feature tracking (CMR-FT) for analysis of left ventricular (LV) strain and strain rate in patients with non-ischemic dilated cardiomyopathy (NIDCM) combined with ventricular arrhythmias (VAs). And evaluated the correlation between the LV global strain and left ventricular ejection (LVEF). We performed a retrospective study in a cohort of 34 consecutive patients with NIDCM combined with VAs who underwent CMR examination in our hospital between January 2016 and December 2019. Global and segmental peak values of LV longitudinal, circumferential, radial strain, and systolic strain rate were analyzed. Pearson analysis was calculated to assess the correlation of LV global deformation and LVEF as well as the correlation of between LV global deformation. Compared with the healthy controls, the global peak radial strain (GPRS), global peak circumferential strain (GPCS), and global peak longitudinal strain (GPLS) were significantly reduced in patients with NIDCM combined with VAs (P < 0.001, respectively). Additionally, Pearson analysis showed GPCS negatively correlated with LVEF (r=-0.946, P < 0.001), GPLS negatively correlated with LVEF (r=-0.860, P < 0.001), and GPRS positively correlated with LVEF (r = 0.920, P < 0.001). CMR-FT is a feasible and promising technique for assessing LV myocardial deformation of patients with NIDCM combined with VAs. And, GPCS was better negatively correlated with LVEF and higher reproducibility of intra-class correlation coefficient (ICC), which can help to guide clinical treatment and have great implication on clinical decision.
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Ma et al. (2021) conducted a case-control in Non-ischemic dilated cardiomyopathy combined with ventricular arrhythmias (n=59). Cardiovascular magnetic resonance feature tracking (CMR-FT) vs. Healthy controls was evaluated on Global peak circumferential strain (GPCS) (p=<0.001). Cardiovascular magnetic resonance feature tracking revealed that global peak circumferential strain was significantly impaired in patients with non-ischemic dilated cardiomyopathy and ventricular arrhythmias compared to healthy controls.
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