Key result
Removing trabeculae carneae in computational models of the human left ventricle increased diastolic compliance (enlarged EDV and reduced wall stiffness) while maintaining systolic function.
Why the study?
The role of trabeculae carneae in diastolic and systolic functions of the left ventricle is not well understood.
Computational modeling indicates that trabeculae carneae play a role in left ventricular mechanics, with their absence increasing diastolic compliance while maintaining systolic function.
Computational models suggest trabecular modification could aid diastolic filling; leaves open validation and therapeutic relevance in human HF.
Trabeculae carneae are irregular structures that cover the endocardial surfaces of both ventricles and account for a significant portion of human ventricular mass. The role of trabeculae carneae in diastolic and systolic functions of the left ventricle (LV) is not well understood. Thus, the objective of this study was to investigate the functional role of trabeculae carneae in the LV. Finite element (FE) analyses of ventricular functions were conducted for three different models of human LV derived from high-resolution magnetic resonance imaging (MRI). The first model comprised trabeculae carneae and papillary muscles, while the second model had papillary muscles and partial trabeculae carneae, and the third model had a smooth endocardial surface. We customized these patient-specific models with myofiber architecture generated with a rule-based algorithm, diastolic material parameters of Fung strain energy function derived from biaxial tests and adjusted with the empirical Klotz relationship, and myocardial contractility constants optimized for average normal ejection fraction (EF) of the human LV. Results showed that the partial trabeculae cutting model had enlarged end-diastolic volume (EDV), reduced wall stiffness, and even increased end-systolic function, indicating that the absence of trabeculae carneae increased the compliance of the LV during diastole, while maintaining systolic function.
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Fatemifar et al. (2019) studied Left ventricular function. Removal of trabeculae carneae (computational model) vs. Intact trabeculae carneae model was evaluated on Diastolic and systolic functions. Removing trabeculae carneae in computational models of the human left ventricle increased diastolic compliance (enlarged EDV and reduced wall stiffness) while maintaining systolic function.
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