Minimisation: the platinum standard for trials?

Tom Treasure; K D MacRae

doi:10.1136/bmj.317.7155.362

August 8, 1998BMJOpen Access

Minimisation: the platinum standard for trials?

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Key Points

To examine whether standard randomisation adequately balances prognostic determinants across study arms and assess whether minimisation offers a superior allocation strategy.
Critically analyzed the theoretical assumptions underlying conventional randomised controlled trials regarding baseline group equivalence.
Assessed standard clinical reporting practices for baseline factors, including demographics, cardiovascular risk factors, and organ function.
Standard randomisation relies purely on probability, which does not guarantee equal distribution of key prognostic variables across trial groups.
Minimisation dynamically balances participant characteristics between treatment arms, directly preventing baseline discrepancies that could distort measured treatment effects.

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Implication

Methodological analysis evaluates baseline covariate balance in clinical trials, suggesting minimisation may provide superior control over confounding factors.

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Cite This Study

Treasure et al. (1998) studied this question.

synapsesocial.com/papers/6a16691aa8d6c30f74623ec4 https://doi.org/10.1136/bmj.317.7155.362

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Minimisation: the platinum standard for trials?

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Minimisation: the platinum standard for trials?

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

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