Key result
Higher molecular weight NT-isoforms of titin play a key role in maintaining sarcomere structure and contractile function in mammalian striated muscles during adaptive and pathological processes.
Population
Vertebrate striated muscles under normal conditions, during hibernation, real and simulated microgravity…
Design
Review
Authors
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Hypothesis-generating for titin in muscle disorders; leaves open clinical translation pending interventional studies.
This review highlights the discovery of novel high molecular weight NT-isoforms of titin and their critical role in maintaining sarcomere structure and contractile function in mammalian striated muscles.
Vikhlyantsev et al. (2012) conducted a review in Normal and pathological conditions (stiff-person syndrome, post-apoplectic spasticity, dilated cardiomyopathy, cardiac hypertrophy). Higher molecular weight NT-isoforms of titin play a key role in maintaining sarcomere structure and contractile function in mammalian striated muscles during adaptive and pathological processes.
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