Allogeneic transplantation versus intensive chemotherapy in first-remission acute leukemia: is there a "best choice"?

Robert J. Mayer

doi:10.1200/jco.1988.6.10.1532

October 1, 1988Journal of Clinical Oncology

Allogeneic transplantation versus intensive chemotherapy in first-remission acute leukemia: is there a "best choice"?

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Key Points

To evaluate whether allogeneic bone marrow transplantation provides superior outcomes compared to intensive consolidation chemotherapy for acute leukemia during first complete remission.
Reviewed clinical outcomes and comparative evidence evaluating allogeneic hematopoietic transplantation versus multi-agent intensive chemotherapy.
Assessed post-remission strategies focusing on disease relapse rates, treatment-related toxicity, and overall survival in patients with acute leukemia.
Allogeneic transplantation provides strong antileukemic efficacy that reduces relapse rates but carries substantial treatment-related morbidity and mortality.
Intensive consolidation chemotherapy avoids graft-versus-host complications but remains associated with higher rates of leukemia recurrence, indicating that neither option serves as a universal standard for all patients.

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Implication

Comparative review evaluates post-remission strategies in acute leukemia, highlighting trade-offs between allogeneic transplantation and intensive chemotherapy.

Abstract

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1988.6.10.1532 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3049948 Allogeneic transplantation versus intensive chemotherapy in first-remission acute leukemia: is there a "best choice"? R J MayerxR J MayerSearch for articles by this author Show More Dana-Farber Cancer Institute, Boston. https://doi.org/10.1200/JCO.1988.6.10.1532 First Page PDF © 1988 by American Society of Clinical Oncology

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Robert J. Mayer (1988) studied this question.

synapsesocial.com/papers/6a1677417729da44b7655b09 https://doi.org/10.1200/jco.1988.6.10.1532

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Allogeneic transplantation versus intensive chemotherapy in first-remission acute leukemia: is there a "best choice"?

Key Points

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Abstract

Discussion

Cite This Study

Allogeneic transplantation versus intensive chemotherapy in first-remission acute leukemia: is there a "best choice"?

Key Points

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Implication

Abstract

Discussion

Cite This Study

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