Key result
Disease-related symptoms and impairments accounted for ≥30% of the effect of chronic diseases on universal health outcomes, with heart failure increasing the hazard of death (HR 6.5; 95% CI 4.7-8.9).
Cross-Sectional (n=8,360)
Yes
Effect estimate: HR 6.5 (95% CI 4.7-8.9)
p-value: p=<.001
Disease-related symptoms and impairments account for a substantial portion of the association between chronic diseases and universal health outcomes, suggesting they are key targets for clinical decision-making.
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Symptoms may merit targeting in chronic disease care; leaves open causal effects and need for prospective trials.
Tinetti et al. (2011) conducted a cross-sectional in Chronic diseases (heart failure, COPD, osteoarthritis, cognitive impairment) (n=8,360). Disease-related symptoms and impairments vs. No disease or symptoms was evaluated on Universal health outcomes (self-rated health, basic and instrumental activities of daily living, and death) (HR 6.5, 95% CI 4.7-8.9, p=<.001). Disease-related symptoms and impairments accounted for ≥30% of the effect of chronic diseases on universal health outcomes, with heart failure increasing the hazard of death (HR 6.5; 95% CI 4.7-8.9).
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