Key result
Chemical mutagenesis conferred only 1.1- to 2.8-fold increases in mutation frequencies at defined single base sites in vesicular stomatitis virus and poliovirus.
Population
Vesicular stomatitis virus and poliovirus
Design
Preclinical
Authors
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Modest mutagenesis effects observed in these models; leaves open whether lethal mutagenesis can be achieved in vivo.
Chemical mutagenesis only slightly increases mutation frequencies at defined single base sites in vesicular stomatitis virus and poliovirus.
Holland et al. (1990) studied this question. Chemical mutagenesis conferred only 1.1- to 2.8-fold increases in mutation frequencies at defined single base sites in vesicular stomatitis virus and poliovirus.
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