Key result
Higher preoperative urinary creatinine and lower intraoperative urine flow linked to >25% postoperative plasma creatinine increases.
Why the study?
Elevations of plasma creatinine are common following major surgery, but their underlying pathophysiology remains poorly understood.
Population
642 patients undergoing mixed major surgeries, mostly open gastrointestinal
Comparison
Postoperative increase in plasma creatinine >25% vs no increase >25%
Design
Retrospective analysis of pooled data from eight prospective studies across four countries
Follow-up
First postoperative morning
Authors
Loading...
Postoperative creatinine rises may reflect fluid retention rather than AKI; hypothesis-generating and should not yet change practice.
Cohort (n=642)
Yes
Absolute Event Rate: 11% vs 8.3%
p-value: p=<0.001
Postoperative elevation of plasma creatinine is strongly associated with preoperative concentrated urine and intraoperative low urine flow, suggesting it may reflect physiological fluid retention rather than acute kidney injury.
Hahn et al. (2023) conducted a cohort in Mixed major surgeries (n=642). Postoperative increase in plasma creatinine >25% vs. Postoperative increase in plasma creatinine ≤25% was evaluated on Preoperative urinary creatinine concentration (mmol/L) (p=<0.001). Patients with a postoperative increase in plasma creatinine >25% had significantly higher preoperative urinary creatinine concentrations (11.0 vs 8.3 mmol/L) and lower intraoperative urine flow.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: