What question did this study set out to answer?

To examine the risk of psychotic experiences across depression severity levels and determine whether their co-occurrence produces greater functional and health status impairment than depression alone.

July 5, 2016Psychological Medicine

Risk and functional significance of psychotic experiences among individuals with depression in 44 low- and middle-income countries

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To examine the risk of psychotic experiences across depression severity levels and determine whether their co-occurrence produces greater functional and health status impairment than depression alone.
Analyzed data from 195,479 adults aged ≥18 years across 44 low- and middle-income countries from the World Health Survey.
Categorized past 12-month depression into depressive episode, brief depressive episode, subsyndromal depression, and no depression, and assessed positive psychotic symptoms using the Composite International Diagnostic Interview.
Evaluated seven functional health domains and interviewer-rated mental health problems using multivariable logistic and linear regression models.
Depression significantly increased the odds of reporting psychotic experiences compared with no depression across subsyndromal depression (OR 2.38, 95% CI 2.02–2.81), brief depressive episodes (OR 3.84, 95% CI 3.31–4.46), and depressive episodes (OR 3.75, 95% CI 3.24–4.33).
Co-occurring psychotic experiences and depression were associated with significantly greater impairment in cognition, interpersonal activities, and sleep/energy domains, as well as higher odds of observable illness behavior, compared to depression alone.

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Implication

Cross-sectional survey finds psychotic experiences worsen functional disability and illness behavior in depression, highlighting the need for combined screening.

Cite This Study

Koyanagi et al. (2016) studied this question.

synapsesocial.com/papers/6a1688a10c3d638cb0bc18a2 https://doi.org/10.1017/s0033291716001422

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Implication

Cross-sectional survey finds psychotic experiences worsen functional disability and illness behavior in depression, highlighting the need for combined screening.

Risk and functional significance of psychotic experiences among individuals with depression in 44 low- and middle-income countries

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Discussion

Implication

Cite This Study

Risk and functional significance of psychotic experiences among individuals with depression in 44 low- and middle-income countries

Key Points

Discussion

Implication

Cite This Study

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