Implementation and Evaluation of DASC and DASC/DOT as Complementary Metrics to DOT: A 5-Year Retrospective Observational Study at the Cancer Center

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Key Points

This research aims to assess the limitations of Days of Therapy (DOT) and introduce a new metric, Days of Antibiotic Spectrum Coverage (DASC), in evaluating antibiotic usage at a cancer center.
Conducted a 5-year retrospective observational study using patient data from 2019 to 2023.
Analyzed antimicrobial usage metrics: DOT, DASC, and DASC/DOT, stratifying patients by solid tumors and hematologic malignancies.
Evaluated trends in antimicrobial usage over time and variations between different patient groups.
Overall, DOT and DASC significantly increased during the study period, while DASC/DOT showed a significant decrease.
There was a notable difference in the trends of DASC/DOT between solid tumor and hematologic malignancy patients.
The findings suggest the potential for more targeted interventions in antibiotic stewardship activities.

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Retrospective analysis evaluates antimicrobial use metrics in hospitalized patients, suggesting improvements in interventions.

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Ogawa et al. (2025) studied this question.

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