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Demonstrates enhanced wound healing and MRSA reduction using a composite film in skin infections, indicating promising therapeutic potential.
• The combination of chitosan, polyvinylpyrrolidone, adjuvant surfactin, and the antimicrobial agent platensimycin (PTM) enables the formation of a crosslinked film. • The crosslinking mechanism arises from the formation of hydrogen bonds and electrostatic interactions among the components. • The prepared film exhibited synergistic anti-MRSA performance, with a greater than 64-fold rise in its bacterial kill rate. • The PTM-loaded composite film exhibited significant efficacy in ameliorating MRSA infection and promoting skin wound repair.
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Xiong et al. (2026) studied this question.
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