Expression Profiles of α1nAChR, ERK1/2, c-FOS and Matrix Metalloproteinases Among Male Smokers with Acute Coronary Syndrome

Figures

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  Figure 1. The gene expression of α1nAChR, ERK 1/2, and c-FOS in the atherosclerotic plaque of smokers and non-smokers. Values are presented as mean ± SEM. The asterisk denotes significant differences between smokers and non-smokers at * p < 0.05 with n = 26.

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  Figure 2. The gene expression of α1nAChR, ERK 1/2, and c-FOS in the PBMCs of ACS and CCS groups according to smoking status, before and after covariate adjustment. Values are presented as mean ± SEM with n = 30. a p = 0.040 ACS + S vs. CCS + S; b p = 0.004 ACS + NS vs. CCS + S; c p = 0.026 ACS + NS vs. CCS + NS; a p = 0.047 CCS + S vs. CCS + NS; b p = 0.003 ACS + NS vs. CCS + S; c p = 0.027 ACS + NS vs. CCS + NS; d p < 0.001 ACS + S vs. CCS + NS; e p < 0.001 ACS + S vs. CCS + S; f p < 0.001 ACS + S vs. ACS + NS; d p < 0.001 ACS + S vs. CCS + NS; e p < 0.001 ACS + S vs. CCS + S; f p < 0.001 ACS + S vs. ACS + NS.

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  Figure 3. Mean serum protein levels of MMP-2, MMP-9 and TIMP 3 in the ACS, CCS, and Control groups according to smoking status, before and after covariate adjustment. Values are presented as mean ± SEM with n = 30. a p = 0.036 CCS + S vs. Controls + NS; b p < 0.001 CCS + NS vs. Controls + NS; c p < 0.001 CCS + NS vs. Controls + S; d p < 0.001 CCS + S vs. Controls + NS; e p < 0.001 CCS + S vs. Controls + S; f p = 0.022 CCS + S vs. CCS + NS; g p < 0.001 ACS + NS vs. Controls + NS; h p < 0.001 ACS + NS vs. Controls + S; i p = 0.004 ACS + NS vs. CCS + NS; j p < 0.001 ACS + S vs. Controls + NS; k p < 0.001 ACS + S vs. Controls + S; l p = 0.015 ACS + S vs. CCS + NS; b p < 0.001 CCS + NS vs. Controls + NS; c p = 0.004 CCS + NS vs. Controls + S; d p < 0.001 CCS + S vs. Controls + NS; e p < 0.001 CCS + S vs. Controls + S; f p = 0.036 CCS + S vs. CCS + NS; g p < 0.001 ACS + NS vs. Controls + NS; h p < 0.001 ACS + NS vs. Controls + S; i p = 0.005 ACS + NS vs. CCS + NS; j p < 0.001 ACS + S vs. Controls + NS; k p < 0.001 ACS + S vs. Controls + S; l p = 0.035 ACS + S vs. CCS + NS; m p < 0.001 CCS + NS vs. Controls + NS; n p < 0.001 CCS + NS vs. Controls + S; o p < 0.001 CCS + S vs. Controls + NS; p p <…