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This review examines the role of mitochondrial dysfunction in Alzheimer’s disease and its implications for pathology and therapy.

Mitochondrial Dysfunction in Alzheimer’s Disease: Beyond Energy Failure Toward a Pathogenic Nexus

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This review examines the role of mitochondrial dysfunction in Alzheimer’s disease and its implications for pathology and therapy.
Comprehensive literature evaluation across molecular, cellular, and systems-level studies.
Focus on bioenergetic collapse, redox imbalance, and mitochondrial dynamics.
Discussion of novel mechanisms like mitochondria-associated membranes and mitochondrial unfolded protein response.
Alzheimer’s disease exhibits mitochondrial abnormalities like impaired oxidative phosphorylation and increased reactive oxygen species (ROS).
Direct mitochondrial accumulation of amyloid-beta and tau affects protein import and respiratory chain function.
Therapeutic strategies include antioxidants and mitochondrial biomarkers for diagnosis and monitoring.

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Review evaluates mitochondrial dysfunction impacts in Alzheimer’s disease, suggesting new therapeutic and diagnostic avenues.

Sridhar et al. (2026) studied this question.

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