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May 27, 2026Journal of Dietary Supplements0 citations

Effects of Human Lactoferrin (Effera ® ) at Two Doses Versus Bovine Lactoferrin on the Adult Gut Microbiome and Fecal Short-Chain Fatty Acids: a Randomized, Double-Blind Trial

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RPRoss D. PetersonJMJulian van der MadeSDSharon M. Donovan

Key Points

  • This trial aims to compare the effects of human lactoferrin and bovine lactoferrin on the adult gut microbiome and fecal short-chain fatty acids.
  • Conducted as a randomized, double-blind trial
  • Compared two doses of human lactoferrin to bovine lactoferrin
  • Data analyzed on microbial diversity and short-chain fatty acid levels.
  • Supplementation increased acetate levels and potentially beneficial taxa
  • Maintained microbial diversity without disrupting community structure
  • Microbiome findings are exploratory and hypothesis-generating.

Abstract

supplementation promoted a proportional increase in acetate and supported potentially beneficial taxa while maintaining microbial diversity, without disrupting community structure. As a pre-specified exploratory outcome, microbiome and VFA findings should be interpreted as hypothesis-generating. (clinicaltrials.gov: NCT06012669).

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Cite This Study

Peterson et al. (2026) studied this question.

synapsesocial.com/papers/6a1689eb0c924ddd1bd589a2https://doi.org/10.1080/19390211.2026.2673021
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Also Consider

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  5. 5Structure of human lactoferrin at 3.2-A resolution.1987 · 384 citations