MR elastography of the human heart: Noninvasive assessment of myocardial elasticity changes by shear wave amplitude variations
Key result
Magnetic resonance elastography demonstrated that myocardial wave amplitudes were up to 2.45 higher during diastole than systole, indicating a 37.7-fold maximum change in wall stiffness.
Why the study?
Does magnetic resonance elastography allow noninvasive assessment of myocardial elasticity changes over the cardiac cycle in healthy volunteers?
Population
6 healthy volunteers
Authors
Discussion
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Implication
MRE enables noninvasive assessment of cyclic myocardial stiffness changes in healthy hearts; leaves open validation and utility in cardiac disease.
Study Design
Type
Observational (n=6)
Structured PICO
Does magnetic resonance elastography allow noninvasive assessment of myocardial elasticity changes over the cardiac cycle in healthy volunteers?
P
Population
6 healthy volunteers
I
Intervention
Magnetic resonance elastography (MRE) technique using low-frequency shear vibrations of 24.3 Hz induced via the anterior chest wall and an ECG-triggered, steady-state MRE sequence
O
Outcome
Changes in myocardial elasticity over the cardiac cycle measured by shear wave amplitude variationssurrogate
MR elastography is a feasible noninvasive technique to measure significant dynamic changes in myocardial wall stiffness throughout the cardiac cycle.
Cite This Study
Sack et al. (2008) conducted an observational in Healthy volunteers (n=6). Magnetic resonance elastography (MRE) was evaluated on Changes in myocardial elasticity over the cardiac cycle. Magnetic resonance elastography demonstrated that myocardial wave amplitudes were up to 2.45 higher during diastole than systole, indicating a 37.7-fold maximum change in wall stiffness.